In 1860, Drusilla was introduced to Angelus. An innocent young woman who was gifted with the ability to see the future. Angelus decided to make Drusilla his special toy and began to ruthlessly dismantle her sanity. He posed as a priest and told the naïve young lass that her visions were the work of Satan, from whom she was spawned, and there was no hope for her soul but to give in to evil and fulfill the Lord's prophecy. He then went to her home and slaughtered her entire family in front of her.

Drusilla was able to escape to a convent on the countryside where she would attempt to become a nun to help cleanse her soul of the horrors she had experienced. But Angelus caught up to her and, on the day she was to take the veil, he descended upon the convent and massacred every last nun. Afterwards, he made love to Darla in front of the quivering, now- insane Drusilla and then sired his conquest into vampiredom.

The three savage vamps traveled to Budapest, among other regions, and in 1880 found themselves back in England butchering mortals in the streets of London. By this time, Drusilla began to thirst for the intimate companionship that Darla and Angelus had and so decided to find a man to share eternity with. Her quest ended quickly when she spotted a skinny, insecure poet named William. Drusilla sired the easily-seduced outcast, and he was resurrected as the vampire known today as Spike.

After becoming well acquainted with each other, Angelus, Darla, Drusilla and Spike set up camp in Yorkshire, where they hunted as a disciplined pack. Although they were experiencing blood-drenched prosperity under the leadership of Angelus, Spike's brazen attempt at gaining notoriety drew too much attention to the crafty predators, and they were forced to move on.

By 1898, Angelus, Darla, Spike and Drusilla had brought their whirlwind of slaughter to Borsa, Romania. She was almost killed herself by an angry crowd in Prague. Spike saved her and has been working to restore her to her full power. Cunning, deadly and deranged, Drusilla at full strength is a formidable enemy.